MRmediation: A Causal Mediation Method with Methylated Region (MR) as the Mediator

A causal mediation approach under the counterfactual framework to test the significance of total, direct and indirect effects. In this approach, a group of methylated sites from a predefined region are utilized as the mediator, and the functional transformation is used to reduce the possible high dimension in the region-based methylated sites and account for their location information.

Version: 1.0.1
Depends: R (≥ 3.5.0), fda
Imports: MASS, stats
Published: 2020-12-17
DOI: 10.32614/CRAN.package.MRmediation
Author: Qi Yan
Maintainer: Qi Yan <qy2253 at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: MRmediation results


Reference manual: MRmediation.pdf


Package source: MRmediation_1.0.1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): MRmediation_1.0.1.tgz, r-oldrel (arm64): MRmediation_1.0.1.tgz, r-release (x86_64): MRmediation_1.0.1.tgz, r-oldrel (x86_64): MRmediation_1.0.1.tgz
Old sources: MRmediation archive


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