RestoreNet: Random-Effects Stochastic Reaction Networks

A random-effects stochastic model that allows quick detection of clonal dominance events from clonal tracking data collected in gene therapy studies. Starting from the Ito-type equation describing the dynamics of cells duplication, death and differentiation at clonal level, we first considered its local linear approximation as the base model. The parameters of the base model, which are inferred using a maximum likelihood approach, are assumed to be shared across the clones. Although this assumption makes inference easier, in some cases it can be too restrictive and does not take into account possible scenarios of clonal dominance. Therefore we extended the base model by introducing random effects for the clones. In this extended formulation the dynamic parameters are estimated using a tailor-made expectation maximization algorithm. Further details on the methods can be found in L. Del Core et al., (2022) <doi:10.1101/2022.05.31.494100>.

Version: 1.0
Depends: R (≥ 2.10)
Imports: Matrix, xtable, scales, stringr, ggplot2, scatterpie, RColorBrewer
Suggests: R.rsp
Published: 2022-09-20
Author: Luca Del Core ORCID iD [aut, cre, cph], Marco Grzegorczyk ORCID iD [aut, ths], Ernst Wit ORCID iD [aut, ths]
Maintainer: Luca Del Core <l.del.core at>
License: GPL-3
NeedsCompilation: no
CRAN checks: RestoreNet results


Reference manual: RestoreNet.pdf
Vignettes: Using RestoreNet


Package source: RestoreNet_1.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): RestoreNet_1.0.tgz, r-oldrel (arm64): RestoreNet_1.0.tgz, r-release (x86_64): RestoreNet_1.0.tgz, r-oldrel (x86_64): RestoreNet_1.0.tgz


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